GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7692995 | 1 | rs6840868 | chr4:17939331 | DCAF16 | chr4:17802280-17812381:- | -0.2 | -4.48 | 9.3E-6 | Height |
| THCA | cis | rs7692995 | 1 | rs6841793 | chr4:17933810 | DCAF16 | chr4:17802280-17812381:- | -0.22 | -4.83 | 1.86E-6 | Height |
| THCA | cis | rs6841898 | 1 | rs6841898 | chr4:24578097 | LGI2 | chr4:25000471-25032414:- | 0.3 | 3.34 | 0.000893 | Myopia (pathological) |
| THCA | cis | rs7692995 | 1 | rs6842114 | chr4:18008199 | DCAF16 | chr4:17802280-17812381:- | -0.2 | -4.57 | 6.12E-6 | Height |
| THCA | cis | rs7692995 | 1 | rs6843330 | chr4:17952056 | DCAF16 | chr4:17802280-17812381:- | -0.2 | -4.36 | 1.59E-5 | Height |
| THCA | cis | rs7692995 | 1 | rs6845078 | chr4:17952208 | DCAF16 | chr4:17802280-17812381:- | -0.18 | -4.19 | 3.27E-5 | Height |
| THCA | cis | rs7659604 | 1 | rs6846232 | chr4:122664805 | EXOSC9 | chr4:122722472-122738175:+ | 0.15 | 3.96 | 8.71E-5 | Type 2 diabetes |
| THCA | cis | rs1008375 | 1 | rs6846238 | chr4:17629939 | MED28 | chr4:17616273-17629791:+ | 0.2 | 4.4 | 1.33E-5 | Parasitemia in Tripanosoma cruzi seropositivity |
| THCA | cis | rs11097912 | 1 | rs6846579 | chr4:107011756 | TBCK | chr4:106967233-107237861:- | 0.36 | 7.41 | 5.71E-13 | Airflow obstruction |
| THCA | cis | rs10518128 | 1 | rs6847968 | chr4:75715519 | BTC | chr4:75671448-75719882:- | 0.2 | 3.95 | 8.9E-5 | Electroencephalogram traits |
| THCA | cis | rs1008375 | 1 | rs6848360 | chr4:17634442 | MED28 | chr4:17616273-17629791:+ | 0.18 | 3.94 | 9.3E-5 | Parasitemia in Tripanosoma cruzi seropositivity |
| THCA | cis | rs7438704 | 1 | rs6848395 | chr4:48394593 | OCIAD1 | chr4:48833015-48863831:+ | 0.13 | 4.02 | 6.83E-5 | Crohn's disease;Inflammatory bowel disease |
| THCA | cis | rs10518128 | 1 | rs6848411 | chr4:75715789 | BTC | chr4:75671448-75719882:- | 0.2 | 3.95 | 8.9E-5 | Electroencephalogram traits |
| THCA | cis | rs685001 | 1 | rs685001 | chr1:48025063 | FOXD2 | chr1:47901689-47906362:+ | 0.25 | 4.35 | 1.67E-5 | Obesity-related traits |
| THCA | cis | rs685001 | 1 | rs685001 | chr1:48025063 | MGC12982 | chr1:47897808-47900313:- | 0.2 | 4.22 | 2.89E-5 | Obesity-related traits |